124039-99-2Relevant academic research and scientific papers
Some novel observations on ethoxymethylation of 2-hydroxy- and 2-methoxyphenyl benzyl ketones: Isolation of α-methylene- and α-hydroxymethyl derivatives
Jain, Amolak C.,Nayyar, Naresh K.,Paliwal, Poonam
, p. 10 - 14 (2007/10/02)
Ethoxymethylation of benzyl 2-hydroxyphenyl ketones (6a, 6b and 6c) with two mol equivalents of ethoxymethyl chloride in the presence of K2CO3 and DMF affords directly the isoflavanones (8a, 8b, and 8c respectively) albeit in smaller yields than recorded earlier .In the case of 6a and 6b, α-methylene derivatives (7a and 9) are also formed.However, ethoxymethylation of benzyl-2-methoxyphenyl ketones (10a, 10b and 10c) with one mol equivalent of ethoxymethyl chloride under similar conditions gives invariably the α-methylene derivatives (11a, 11b and 11c respectively) and α-hydroxymethyl derivative (12).
