1240403-77-3Relevant academic research and scientific papers
One-pot synthesis of azanucleosides from proline derivatives stereoselectivity in sequential processes
Boto, Alicia,Hernandez, Dacil,Hernandez, Rosendo
experimental part, p. 3847 - 3857 (2010/09/05)
Common amino acid derivatives can be transformed in onestep fashion into N-azanucleosides. The method is a sequential process initiated, by a domino radical decarboxylation/ oxidation reaction; an acyliminium ion is formed as an intermediate and can be trapped by nitrogen bases (purines, pyrimidines, and benzotriazole). The mildness of the reaction conditions and the good, yields obtained make this procedure an interesting alternative to the conventional processes. Good stereoselectivities were obtained with 4-(silyloxy)proline derivatives as substrates.
