1240407-85-5Relevant academic research and scientific papers
Optimized synthesis of phosphatidylserine
Guanti, Giuseppe,Banfi,Basso,Bondanza,Guglieri,Powles,Riva
experimental part, p. 367 - 373 (2010/12/18)
The synthesis of phosphatidyl serine containing saturated fatty acids was thoroughly studied and optimized in order to establish a protocol amenable to large-scale synthesis. The key step was a one-pot multicomponent reaction involving an O-benzyl phosphorodiamidite, protected serine and diacylglycerol, followed by in situ oxidation of the resulting phosphite. In order to replace expensive and poorly stable tetrazole, a screening of substitutes was carried out and imidazolium chloride was selected as the best suited one. Springer-Verlag 2010.
