1240489-75-1Relevant academic research and scientific papers
Broad spectrum alkynyl inhibitors of T315I Bcr-Abl
Deng, Xianming,Lim, Sang Min,Zhang, Jianming,Gray, Nathanael S.
, p. 4196 - 4200 (2010)
A series of alkyne-containing type II inhibitors with potent inhibitory activity of T315I Bcr-Abl has been identified. The most active compound 4 exhibits an EC50 of less than 1 nM against wild-type Bcr-Abl and an EC50 of 10 nM again
