1240496-80-3Relevant academic research and scientific papers
Synthesis and evaluation of 1,2-trans alkyl galactofuranoside mimetics as mycobacteriostatic agents
Dureau, Rémy,Gicquel, Maxime,Artur, Isabelle,Guégan, Jean-Paul,Carboni, Bertrand,Ferrières, Vincent,Berrée, Fabienne,Legentil, Laurent
, p. 4940 - 4952 (2015)
The simple octyl β-d-galactofuranoside was previously described as a good bacteriostatic agent against Mycobacterium smegmatis, a non-pathogenic model of M. tuberculosis. In order to decipher its mechanism of action, STD NMR on whole M. smegmatis cells wa
Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania
Dureau, Remy,Robert-Gangneux, Florence,Gangneux, Jean-Pierre,Nugier-Chauvin, Caroline,Legentil, Laurent,Daniellou, Richard,Ferrieres, Vincent
experimental part, p. 1299 - 1305 (2010/10/02)
The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.
