1240504-52-2Relevant articles and documents
Modification of biologically active amides and amines with fluorine-containing heterocycles: 2*. N-(2-thienyl)imines on the base of methyl trifluoropyruvate in cyclocondensation with 1,3-N, N-binucleophiles
Sokolov,Aksinenko
, p. 197 - 199 (2011/01/10)
An approach to the modification of the biologically active compounds, substituted 2-aminothiophenes, with fluorine-containing five-membered heterocycles is proposed. The reaction of 2-aminothiophenes with methyl trifluoropyruvate yields the corresponding N-(2-thienyl)imines, their subsequent cyclocondensation with 1,3-N,N-binucleophiles (2-aminothiazoline and benzamidines) furnished 5-oxo-6-trifluoromethyl-2,3,5,6- tetrahydroimidazothiazoles and 5-oxo-2-phenyl-4-trifluoromethyl-4,5-dihydro-1 H-imidazoles.