1240507-88-3Relevant articles and documents
Scalable solution-phase synthesis of the biologically active cyclodepsipeptide destruxin E, a potent negative regulator of osteoclast morphology
Yoshida, Masahito,Sato, Hiroshi,Ishida, Yoshitaka,Nakagawa, Hiroshi,Doi, Takayuki
, p. 296 - 306 (2014)
The scalable solution-phase synthesis of the cyclodepsipeptide destruxin E (1) has been achieved. Diastereoselective dihydroxylation of the terminal alkene in a 2-alkoxy-4-pentenoic amide, 7, was successfully accomplished utilizing (DHQD)2PHAL
Synthesis, structure determination, and biological evaluation of destruxin e
Yoshida, Masahito,Takeuchi, Hisayuki,Ishida, Yoshitaka,Yashiroda, Yoko,Yoshida, Minoru,Takagi, Motoki,Shin-Ya, Kazuo,Doi, Takayuki
supporting information; experimental part, p. 3792 - 3795 (2010/11/05)
The total synthesis of destruxin E (1) has been achieved for the first time, and the stereochemistry of its chiral center at the epoxide has been determined to be (S). The cyclization precursor 3a was synthesized by solid-phase peptide synthesis. Macrolac