1240514-97-9Relevant academic research and scientific papers
Development of a highly selective,orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071
Lebois, Evan P.,Digby, Gregory J.,Melancon, Bruce J.,Tarr, James C.,Cho, Hyekyung P.,Miller, Nicole R.,Morrison, Ryan,Bridges, Thomas M.,Xiang, Zixiu,Daniels, J. Scott,Wood, Michael R.,Conn, P. Jeffrey,Lindsley, Craig W.
, p. 6451 - 6455 (2011/11/29)
Herein we report the discovery and SAR of a novel series of M1 agonists based on the MLPCN probe, ML071. From this, VU0364572 emerged as a potent, orally bioavailable and CNS penetrant M1 agonist with high selectivity, clean ancillary pharmacology and enantiospecific activity.
