1240567-67-2Relevant articles and documents
SSAO INHIBITOR
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Paragraph 0573; 0574; 0575, (2020/04/02)
The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.
HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE
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Page/Page column 84, (2019/08/12)
This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.
PHENOXYTRIAZOLES
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Page/Page column 37, (2018/05/27)
The present invention relates to a compound of formula I, HetAr is a five or six membered heteroaryl group, selected from wherein R1 is hydrogen, halogen, lower alkyl, lower alkoxy or lower alkyl substituted by halogen, and may be the same or d
Anilinotriazoles as potent gamma secretase modulators
Velter, Adriana I.,Bischoff, Franois P.,Berthelot, Didier,De Cleyn, Michel,Oehlrich, Daniel,Jaroskova, Libuse,Macdonald, Gregor,Minne, Garrett,Pieters, Serge,Rombouts, Frederik,Van Brandt, Sven,Van Roosbroeck, Yves,Surkyn, Michel,Trabanco, Andrs A.,Tresadern, Gary,Wu, Tongfei,Borghys, Herman,Mercken, Marc,Masungi, Chantal,Gijsen, Harrie
, p. 5805 - 5813 (2015/01/08)
The design and synthesis of a novel series of potent gamma secretase modulators is described. Exploration of various spacer groups between the triazole ring and the aromatic appendix in 2 has led to anilinotriazole 28, which combined high in vitro and in
NOVEL SUBSTITUTED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
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Page/Page column 26, (2012/12/13)
The present invention is concerned with novel substituted triazole derivatives of Formula (I) wherein Het1, R1, R2, A1, A2, A3, A4, L1, and L2 have the mean
NOVEL SUBSTITUTED TRIAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
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Page/Page column 56-57, (2011/08/04)
The present invention is concerned with novel substituted triazole derivatives of Formula (I) wherein Het1, R1, R2, A1, A2, A3, A4, L1, and L2 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma sec