124067-17-0

Basic information

• Product Name: (2R) 1-<(t-butyldiphenylsilyl)oxy>-2-furanylethanol
• Synonyms: (2R) 1-<(t-butyldiphenylsilyl)oxy>-2-furanylethanol
• CAS NO: 124067-17-0
• Molecular Weight: 366.532
• Mol File: 124067-17-0.mol

Chemical Properties

• CAS DataBase Reference: (2R) 1-<(t-butyldiphenylsilyl)oxy>-2-furanylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R) 1-<(t-butyldiphenylsilyl)oxy>-2-furanylethanol(124067-17-0)
• EPA Substance Registry System: (2R) 1-<(t-butyldiphenylsilyl)oxy>-2-furanylethanol(124067-17-0)

Safety Data

• Hazardous Substances Data: 124067-17-0(Hazardous Substances Data)

Upstream product

• 14086-08-9 (R)-2-(2-furyl)-1,2-ethanediol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 188605-65-4 propargyl 6-O-t-butyldiphenylsilyl-2,3-dideoxyhex-2-en-α-D-glucopyranoside 
• 87316-22-1 (2R,3S,4R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-3,4-dihydro-2H-pyran-3,4-diol 

Downstream Products

• 258531-64-5 (S)-2-(tert-Butyldiphenylsilyloxy)-1-(2-furyl)ethyl azide 
• 1018811-55-6 (2R,3S,6S)-2-((tert-butyldiphenylsilyloxy)methyl)-6-methoxy-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-3-ol 
• 1018811-57-8 (6R)-6-((tert-butyldiphenylsilyloxy)methyl)-1-(toluene-4-sulfonyl)-1,6-dihydropyridine-2,5-dione 
• 1018811-52-3 (R)-(2-azido-2-(furan-2-yl)ethoxy)-tert-butyldiphenylsilane 
• 1018811-53-4 (R)-N-[2-(tert-butyldiphenylsilyloxy)-1-(2-furyl)ethyl]-4-methylbenzenesulfonamide 
• 1018811-51-2 (2R,6S)-2-((tert-butyldiphenylsilyloxy)methyl)-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydropyridin-3(2H)-one 
• 1018811-54-5 (2R,6S)-2-((tert-butyldiphenylsilyloxy)methyl)-6-methoxy-1-(toluene-4-sulfonyl)-1,6-dihydropyridin-3(2H)-one 
• 381164-66-5 (S)-2-(tert-butyldiphenylsilyloxy)-1-(furan-2-yl)ethanol 
• 249928-44-7 (S)-1-(furan-2-yl)-2-tert-butyldiphenylsilyloxy-N-(toluene-4-sulfonyl)ethylamine 
• 249928-45-8 (2S,6S)-2-(tert-Butyldiphenylsilyloxymethyl)-6-hydroxy-1-tosyl-1,6-dihydropyridin-3(2H)-one 
• 258531-65-6 (2S,6R)-2-(tert-Butyldiphenylsilyloxymethyl)-6-ethoxy-1-tosyl-1,6-dihydropyridin-3(2H)-one 
• 258531-66-7 (2S,3S,6R)-2-(tert-Butyldiphenylsilyloxymethyl)-6-ethoxy-1-tosylpiperidin-3-ol 

Relevant articles and documents

Furan derivatives, method of synthesis and uses thereof

The present invention relates to furan derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.

Catalytic tin radical mediated tricyclisations. Part 1. Monocyclisation studies

A general strategy for catalytic tin radical mediated, radical cascade reactions is proposed in which three rings are constructed in a single step. The initial step in the tricyclisation process has been examined using 2,3-dideoxy-α-D-erythro-hex-2-enopyr

Transformation of D-glucal to (2S)-hydroxymethyl-dihydropyridones as intermediates to piperidine alkaloids

The efficient transformation of D-glucal to (2S)-hydroxymethyl- dihydropyridone 1 in five steps and 61% overall yield is reported. The latter is used as chiral building block for the synthesis of piperidine alkaloids. The preparation of piperidinol 8, whi

Some unexpected reactivity of propargyl 2,3-dideoxy-2-en-α-D-glucopyranoside derivatives

The formation of (2R) 1-[(t-butyldiphenylsilyl)oxy]-2-furanylethanol (4) and anhydro sugar 13 from propargyl 6-O-t-butyldiphenylsilyl-2,3-dideoxyhex-2-en-α-D-glucopyranoside (1) and propargyl 4-O-allyl-6-O-t-butyldiphenylsilyl-2,3-dideoxyhex-2-en-α-D-gluc

Glycosyl Phosphites as Glycosylation Reagents: Scope and Mechanism

The glycosylation reactions with glycosyl phosphites in the presence of catalytic amounts of TMSOTf at low temperature have been studied with different donors and acceptors for the synthesis of several glycosides, including O-glycosides, S-glycosides, C-glycosides, and glycopeptides.Mechanistic investigations of the reactions indicate that the glycosyl phosphite is activated by either TfOH or TMSOTf, depending on how the substrates are mixed.When the acceptor is treated with TMSOTf first, the glycosyl phosphite is activated by the resulting TfOH.The glycosyl phosphite can also be activated by TMSOTf directly.The best result is, however, to mix the acceptor and TMSOTf first, followed by addition of the glycosyl phosphite.

Chirality transfer from the furan ring transfer reaction

The furan ring transfer (FRT) reactions of optically active propynyl ethers [(1) and (2)] are described, facile chirality transfer from the cycloadduct to the allylic carbon of the product being observed; the stereochemistry of the product was determined