1240700-52-0Relevant academic research and scientific papers
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
Wallace, Michael B.,Adams, Mark E.,Kanouni, Toufike,Mol, Clifford D.,Dougan, Douglas R.,Feher, Victoria A.,O'Connell, Shawn M.,Shi, Lihong,Halkowycz, Petro,Dong, Qing
scheme or table, p. 4156 - 4158 (2010/08/20)
A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.
