1241025-24-0Relevant articles and documents
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides
Kling, Andreas,Jantos, Katja,Mack, Helmut,Hornberger, Wilfried,Drescher, Karla,Nimmrich, Volker,Relo, Ana,Wicke, Karsten,Hutchins, Charles W.,Lao, Yanbin,Marsh, Kennan,Moeller, Achim
, p. 7123 - 7138 (2017/09/07)
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to the ide