1241045-95-3Relevant academic research and scientific papers
Synthesis of labeled ambroxol and its major metabolites
Latli, Bachir,Hrapchak, Matt,Switek, Heinz-Karl,Retz, Daniel M.,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
experimental part, p. 15 - 23 (2010/04/26)
Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Herein, we report the synthesis of carbon-14-labeled ambroxol with the radioactive atom(s) either on the benzylic carbon or uniformly in the cyclohexyl ring with specific activities of 59 and 81 mCi/mmol, respectively. We also describe the preparation of deuterium-labeled ambroxol, its deuterium-labeled tetrahydroquinazoline metabolite (DHTQ), carbon-13-labeled 3,5-dibromoanthranilic acid metabolite, as well as an unlabeled O-glucuronide conjugate. Copyright
