1241052-39-0Relevant academic research and scientific papers
Direct asymmetric aza Diels-Alder reaction catalyzed by chiral 2-pyrrolidinecarboxylic acid ionic liquid
Zheng, Xin,Qian, Yunbo,Wang, Yongmei
experimental part, p. 567 - 570 (2010/08/05)
The utility of [EMIm][Pro] as an efficient catalyst for the one-pot direct asymmetric aza Diels-Alder reaction has been developed. A set of cyclic α,β-unsaturated ketones have been explored in up to 93% yield with up to >99/1 dr and >99% ee. Moreover, the catalytic system can be recycled and reused for six times without any significant loss of catalytic activity.
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
Coleman, Paul J.,Schreier, John D.,Roecker, Anthony J.,Mercer, Swati P.,McGaughey, Georgia B.,Cox, Christopher D.,Hartman, George D.,Harrell, C. Meacham,Reiss, Duane R.,Doran, Scott M.,Garson, Susan L.,Anderson, Wayne B.,Tang, Cuyue,Prueksaritanont, Thomayant,Winrow, Christopher J.,Renger, John J.
scheme or table, p. 4201 - 4205 (2010/08/22)
Orexins are excitatory neuropeptides that regulate arousal and sleep. Orexin receptor antagonists promote sleep and offer potential as a new therapy for the treatment of insomnia. In this Letter, we describe the synthesis of constrained diazepanes having
