1241389-01-4Relevant academic research and scientific papers
Asymmetric vinylogous Michael reaction of α,β-unsaturated ketones with γ-butenolide under multifunctional catalysis
Huang, Huicai,Yu, Feng,Jin, Zhichao,Li, Wenjun,Wu, Wenbin,Liang, Xinmiao,Ye, Jinxing
supporting information; experimental part, p. 5957 - 5959 (2010/11/04)
A general and direct organocatalytic asymmetric vinylogous Michael reaction of γ-butenolide with α,β-unsaturated ketones was investigated with a multifunctional primary amine salt as catalyst. The reaction enables straightforward access toward synthetically versatile γ-substituted butenolides from simple 2(5H)-furanone with satisfactory yields, diastereo- and enantioselectivities (up to 30:1 dr and 95-99% ee).
