124151-46-8Relevant academic research and scientific papers
Pmc-protected amino acid esters as substrates in N-alkylamino acid synthesis
Wisniewski, Kazimierz,Kollodziejczyk, Aleksandra S.
, p. 483 - 486 (1997)
N-alkylamino acids may be synthesised via Mitsunobu reaction of N-(2,2,5,7,8-pentamethylchroman-6-sulphonyl-)-amino acid esters with various alcohols and subsequent deprotection.
Sodium borohydride: A versatile reagent in the reductive N-monoalkylation of α-amino acids and α-amino methyl esters
Verardo, Giancarlo,Geatti, Paola,Pol, Elena,Giumanini, Angelo G.
, p. 779 - 788 (2007/10/03)
α-Amino acids and α-amino methyl esters are easily converted to their N-monoalkyl derivatives by a reductive condensation reaction using several carbonyl compounds in the presence of sodium borohydride. This reducing agent has shown a wide versatility with minor but essential procedural variations. The reaction allows the α-monodeuterium labeling of the new N-substituent by use of sodium borodeuteride.
