124154-68-3Relevant academic research and scientific papers
Cu-catalyzed efficient synthetic methodology for ebselen and related se-N heterocycles
Balkrishna, Shah Jaimin,Bhakuni, Bhagat Singh,Chopra, Deepak,Kumar, Sangit
supporting information; experimental part, p. 5394 - 5397 (2011/02/26)
An efficient copper-catalyzed method for the synthesis of biologically important ebselen and related analogues containing a Se-N bond has been developed. This is the first report of a catalytic process of selenation and Se-N bond formation reaction. Copper-catalyzed reaction tolerates functional groups such as amides, hydroxyls, ethers, nitro, fluorides, and chlorides. The best results are obtained by using a combination of potassium carbonate as a base, iodo- or bromo-arylamide substrates, selenium powder, and copper iodide catalyst.
STABILISATION OF CONDENSED SELENIUM HETEROCYCLES BY A NITRO GROUP IN THE ORTHO-POSITION TO THE CHALCOGEN.
Lambert, Christian,Christiaens, Leon
, p. 9053 - 9060 (2007/10/02)
The synthesis of the 7-nitro-2-phenyl-1,2-benzisoselenazol-3(2H)-one 3a leads to an abnormal behavior due to a dipole stabilisation between the nitro group and the selenium atom.The first ever synthesis of a 2,1-benzoxaselenol-3-one 5 is described.The une
