124154-97-8Relevant academic research and scientific papers
Metal Complexes of Biologically Important Ligands, LIII - Chiral Half-Sandwich Complexes of Rhodium(III), Iridium(III), Iridium(I) and Ruthenium(II) with α-Amino Acid Anions
Kraemer, Roland,Polborn, Kurt,Wanjek, Herbert,Zahn, Ingo,Beck, Wolfgang
, p. 767 - 778 (2007/10/02)
The chloro-bridged metal compounds Cp*(Cl)M(μ-Cl)2M(Cl)Cp* (M = Rh, Ir; Cp* = η5-C5Me5), (η6-C6H6)(Cl)Ru(μ-Cl)2Ru(Cl)(η6-C6H6), and (COD)Ir(μ-Cl)2Ir(COD) react with α-amino acidates to give monomeric chelate complexes Cp*(Cl)M(L-L') (1) (M = Rh, Ir; L-L' = GlyO, L-ValO, L-PheO, PhenylglyO, L-TrpO, L-ProO, L-HisO, L-AspO, L-azetidine-2-carboxylate), Cp*M(L-AspO,O') (2) (M = Rh, Ir), *(Cl)Ir(L-HisOH)>+Cl- (3), (η6-C6H6)(Cl)Ru(L-L') (4) (L-L' = L-ProO, L-PheO, L-p-NO2PheO, L-DopaO, D-PhenylglyO), 6-C6H6)Ru(L-HisO)>+Cl- (5), and(COD)Ir(L-L') (7, 8) (L-L' = L-AlaO, L-PheO, L-ValO, L-LeuO, L-PhenylglyO, L-1-aminocyclopropanecarboxylate), respectively.The complexes 1-5 have a stereogenic metal atom.Similarly, the cleavage of chloro bridges in (COD)Ir(μ-Cl)2Ir(COD) by α-amino acid esters affords the complexes (COD)(Ir(Cl)L (6) (L = GlyOEt, L-AlaOMe, L-ValOMe).The diastereoisomers of 1, 3, and 4 can be detected by NMR spectroscopy.With prolinate a diastereoselectivity up to 92:8 is archieved.The structures of Cp*(Cl)Ir(L-ProO) (1j), Cp*(Cl)Rh(L-azetidine-2-carboxylate) (1m), *(Cl)Ir(L-HisOH)>Cl (3), and (η-C6H6)(Cl)Ru(L-ProO) (4a) have been determined by X-ray crystallography.
