1241581-76-9Relevant academic research and scientific papers
"viologen"dendrimers as antiviral agents: The effect of charge number and distance
Asaftei, Simona,De Clercq, Erik
, p. 3480 - 3488 (2010)
A series of "viologen"derivatives (4,4′-bipyridinium salts) carrying between 1 and 90 charges per molecule have been prepared and investigated for their activity against human immunodeficiency virus (HIV), herpes simplex virus (HSV), vesicular stomatitis, Punta Toro virus, Sindbis virus, Reovirus, and respiratory syncytial viruses. In general, most of the compounds showed good activities against HIV-1 (strain IIIB). In particular, compound 36 exhibited the highest in vitro activity and selectivity index against HIV-1 (strain IIIB) (EC50 = 0.26 ± 0.08 μM, SI = 75.7) in MT-4 cells. The results imply that the antiviral activity requires an optimal number and distance of the positive charges.
HIV-1 X4 activities of polycationic Viologen based dendrimers by interaction with the chemokine receptor CXCR4: Study of structure-activity relationship
Asaftei, Simona,Huskens, Dana,Schols, Dominique
, p. 10405 - 10413 (2013/02/23)
A series of viologen based dendrimers with polycationic scaffold carrying 10, 18, 26, 42, and 90 charges per molecule were used to determine the structure-activity relationship (SAR) with regard to HIV-1 inhibitory activity. The studies involved five comp
