124167-46-0 Usage
Uses
Used in Organic Synthesis:
4-Methylumbelliferyl 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-galactopyranoside is used as an intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structure, which includes sugar and acetyl groups, makes it a versatile building block for the synthesis of bioactive compounds and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methylumbelliferyl 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-galactopyranoside is used as a key component in the development of new drugs, particularly those targeting carbohydrate-related biological processes. Its ability to interact with specific biological receptors and enzymes makes it a valuable tool in the design and synthesis of novel therapeutic agents.
Used in Research and Development:
4-Methylumbelliferyl2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-galactopyranoside is also utilized in research and development settings, where it serves as a valuable reagent for studying the structure and function of various biological molecules. Its unique properties allow researchers to probe the interactions between carbohydrates and other biomolecules, leading to a better understanding of carbohydrate biology and its role in various diseases.
Used in Analytical Chemistry:
4-Methylumbelliferyl 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-galactopyranoside can be employed in analytical chemistry as a derivatizing agent for the detection and quantification of specific compounds, such as sugars and other carbohydrate derivatives. Its light yellow color and unique chemical properties make it suitable for use in various analytical techniques, including chromatography and spectroscopy.
Check Digit Verification of cas no
The CAS Registry Mumber 124167-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,1,6 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 124167-46:
(8*1)+(7*2)+(6*4)+(5*1)+(4*6)+(3*7)+(2*4)+(1*6)=110
110 % 10 = 0
So 124167-46-0 is a valid CAS Registry Number.
124167-46-0Relevant academic research and scientific papers
Profiling of glycosidase activities using coumarin-conjugated glycoside cocktails
Park, Sungjin,Shin, Injae
, p. 619 - 622 (2007/10/03)
Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.
Synthesis of 4-methylumbelliferyl glycosides for the detection of α- and β-D-galactopyranosaminidases
Szweda, R.,Spohr, U.,Lemieux, R. U.,Schindler, D.,Bishop, D. F.,Desnick, R. J.
, p. 1388 - 1391 (2007/10/02)
Reaction at room temperature of either 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α- of β-D-galactopyranosyl chloride with a twofold excess of 4-methylumbelliferone and silver trifluoromethanesulfonate in dichloromethane containing an equimolar amount of sym-collidine yielded 4-methylumbelliferyl tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranoside in 33percent yield.The β anomer was formed in 20 and 10percent yields, respectively.Reduction of the azido group, acetylation followed by de-O-acetylation, provided the desired 4-methylumbelliferyl 2-acetamido-2-deoxy-α- and β-D-galactopyranosides (N-acetyl-α- and β-D-galactopyranosaminides).The α-glycoside proved to be an effective substrate for the highly sensitive fluorimetric detection of N-acetyl-α-D-galactopyranosaminidase activity in human tissues and was used to examine the deficiency of this activity, which is the enzymatic defect in Schindler disease.Key words: synthesis of 4-methylumbelliferyl N-acetyl-α- and β-D-galactopyranosaminides, N-acetyl-α-D-galactosaminidase deficiency (Schindler disease).
