1241677-87-1

Basic information

• Product Name: (2R)-2-amino-3-(3-iodophenyl)propanoic acid
• Synonyms: (R)-2-Amino-3-(3-iodophenyl)propanoic acid; 3-Iodo-D-Phenylalanine
• CAS NO: 1241677-87-1
• Molecular Formula: C₉H₁₀INO₂
• Molecular Weight: 291.08567
• Mol File: 1241677-87-1.mol
• Article Data: 4

Chemical Properties

• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (2R)-2-amino-3-(3-iodophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-amino-3-(3-iodophenyl)propanoic acid(1241677-87-1)
• EPA Substance Registry System: (2R)-2-amino-3-(3-iodophenyl)propanoic acid(1241677-87-1)

Safety Data

• Hazardous Substances Data: 1241677-87-1(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R)-2-amino-3-(3-iodophenyl)propanoic acid" is an amino acid that contains an amino group and a carboxylic acid group. It is a derivative of phenylalanine, with an additional iodine atom attached to the phenyl ring. (2R)-2-amino-3-(3-iodophenyl)propanoic acid is commonly used in the synthesis of peptides and pharmaceuticals, particularly in the development of drugs targeting specific receptors or enzymes. It may also have potential applications in the fields of medicinal chemistry and biochemistry, as it can serve as a building block for the creation of novel compounds with therapeutic properties.

Upstream product

• 273221-75-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(3-iodophenyl)propanoic acid 
• 30163-12-3 N-Acetyl-m-iodphenylalanin 
• 30163-12-3 L-N-Acetyl-3-iodphenyl-alanin 

Downstream Products

• 273221-75-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(3-iodophenyl)propanoic acid 

Relevant articles and documents

Alcohol-supported Cu-mediated 18F-fluorination of iodonium salts under “minimalist” conditions

In the era of personalized precision medicine, positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI gain recognition as indispensable tools of clinical diagnostics. A broader implementation of these imaging modalities in clinical routine is closely dependent on the increased availability of established and emerging PET-tracers, which in turn could be accessible by the development of simple, reliable, and efficient radiolabeling procedures. A further requirement is a cGMP production of imaging probes in automated synthesis modules. Herein, a novel protocol for the efficient preparation of 18F-labeled aromatics via Cu-mediated radiofluorination of (aryl)(mesityl)iodonium salts without the need of evaporation steps is described. Labeled aromatics were prepared in high radiochemical yields simply by heating of iodonium [18F]fluorides with the Cu-mediator in methanolic DMF. The iodonium [18F]fluorides were prepared by direct elution of 18F? from an anion exchange resin with solutions of the corresponding precursors in MeOH/DMF. The practicality of the novel method was confirmed by the racemization-free production of radiolabeled fluorophenylalanines, including hitherto unknown 3-[18F]FPhe, in 22–69% isolated radiochemical yields as well as its direct implementation into a remote-controlled synthesis unit.

Alkylation of N′-[(S)-1′-phenylethyl]-N-(diphenylmethylene)glycinamide using a phase transfer catalyst (PTC) for practical asymmetric syntheses of α-amino acid derivatives

The chiral auxiliary mediated stereoselective alkylation reaction of N′-[(S)-1′-phenylethyl]-N-(diphenylmethylene)glycinamide (1) using a phase transfer catalyst (PTC) is described. Alkylation of 1 using 18-crown-6 as a PTC for liquid-solid extraction of KOH in toluene gives best results. This methodology provides a practical protocol for the preparation of a variety of enantio-enriched unnatural α-amino acid derivatives up to 83:17 enantiomeric ratio.