1241677-97-3Relevant articles and documents
Sequential Intermolecular Radical Addition and Reductive Radical Cyclization of Tyrosine and Phenylalanine Derivatives with Alkenes via Photoinduced Decarboxylation: Access to Ring-Constrained γ-Amino Acids
Osaka, Kazuyuki,Usami, Ayuka,Iwasaki, Tomoya,Yamawaki, Mugen,Morita, Toshio,Yoshimi, Yasuharu
, p. 9480 - 9488 (2019/07/08)
Sequential radical addition to alkenes and reductive radical cyclization of phenylalanine and tyrosine derivatives via photoinduced decarboxylation furnished ring-constrained γ-amino acids under mild conditions. A variety of alkenes such as acrylamides and acrylic esters could be employed in the photoinduced radical cascade cyclization. The yields of the ring-constrained γ-amino acids are dependent on the electron-accepting ability and steric hindrance of the alkene used. The proposed sequential reaction can also be applied for direct tethering of dipeptides to yield unique ring-constrained tetrapeptides.
New precursors for direct radiosynthesis of protected derivatives of O-([18F]Fluoromethyl) tyrosine
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Paragraph 0203-0210, (2013/03/26)
The invention describes novel and stable precursors for the direct radiosynthesis of protected derivatives of O-([18F]Fluoromethyl) tyrosines, and methods for obtaining thoses compounds.