124170-23-6

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-3,3-dimethyl-2-fluoro-1,2-benzisothiazole 1,1-dioxide is used as a key intermediate in the synthesis of new drugs for its potential antimicrobial, anti-inflammatory, and antitumor properties. Its unique structure allows for the development of pharmaceutical compounds with improved therapeutic effects, contributing to the advancement of treatments for various diseases and conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2,3-Dihydro-3,3-dimethyl-2-fluoro-1,2-benzisothiazole 1,1-dioxide serves as a valuable building block for the creation of novel pharmaceutical compounds. Its incorporation into drug candidates can lead to the discovery of new therapeutic agents with enhanced efficacy and selectivity, ultimately benefiting patients in need of innovative treatments.

InChI:InChI=1/C9H10FNO2S/c1-9(2)7-5-3-4-6-8(7)14(12,13)11(9)10/h3-6H,1-2H3

Upstream product

• 102362-98-1 3,3-dimethyl-2,3-dihydro-1,2-benzoisothiazole 1,1-dioxide 
• 124170-21-4 2,3-Dihydro-3,3-dimethyl-2-trimethylsilyl-1,2-benzisothiazole 1,1-dioxide 

Downstream Products

• 102362-98-1 3,3-dimethyl-2,3-dihydro-1,2-benzoisothiazole 1,1-dioxide 

Relevant academic research and scientific papers

Cross cage interactions in substituted bicyclo[1.1.]pent-1-yl radicals. Dissociation to [1.1.1]propellane

A series of 3-substituted bicyclo[1.1.1]pent-1-yl radicals, including the 3-fluoro derivative, was generated by bromine atom abstraction from 1-bromo-3-substituted-bicyclo[1.1.1]pentanes and examined by EPR spectroscopy. The exceptionally large hyperfine splittings obtained from magnetic nuclei of the 3-substituents indicated that cross cage electronic interactions were substantial in these species. Bromine atom abstraction by triethylsilyl radicals from 1-bromo-3-fluorobicyclo[1.1.1]pentane was found to take place more rapidly than bromine abstraction from the unsubstituted parent, i. e., the fluorine substituent mediated a significant polar effect. Evidence was found of a novel disproportionation process in which the γ-fluorine atom was transferred from the 3-fluoro radical to a triethylsilyl or to a second bicyclo[1.1.1]pent-1-yl radical; an analogous chlorine atom transfer process was found for the 3-chloro radical. Ab initio MO calculations (6-31G* basis with electron correlation up to MP4) on the 3-fluoro- and 3-methyl-substituted radicals indicated that loss of the substituent to give [1.1.1]propellane would be comparatively easy for both species.

New Fluorinating Reagents. Part II. Preparation and Synthetic Application of a Saccharin Derived N-Fluorosultam

The synthesis of the new saccharin derived N-fluorosultam 1 is described.A comparative study with commercially available N-fluorosulfonamides shows 1 to be a superior fluorinating reagent for the synthesis of α-fluorocarbonyl compounds.