1241735-44-3Relevant academic research and scientific papers
Highly enantio- and diastereoselective reductive aldol reactions catalyzed by chiral spiro bisphosphine oxides
Zhang, Panke,Liu, Jiawang,Wang, Zheng,Ding, Kuiling
, p. 100 - 105 (2015)
A spiro bisphosphine oxide (SpinPO) was found to be an efficient chiral Lewis base catalyst in asymmetric reductive aldol reaction of enones and aldehydes in the presence of trichlorosilane as the reductant, affording a variety of β-hydroxyketones in good yields with moderate to high levels of diastereo- and enantioselectivities.
Enantioselective reductive aldol reaction using tertiary amine as hydride donor
Osakama, Kazuki,Sugiura, Masaharu,Nakajima, Makoto,Kotani, Shunsuke
supporting information; experimental part, p. 4199 - 4201 (2012/08/28)
An efficient method was developed for the enantioselective reductive aldol reaction of α,β-unsaturated ketones with aldehydes in the presence of a Lewis base catalyst; conjugate reduction using a tertiary amine and trichlorosilyl triflate, followed by an aldol reaction with BINAP dioxide (BINAPO) as an organocatalyst, gave the corresponding product in high yield with high stereoselectivity.
Diastereo- and enantioselective reductive aldol reaction with trichlorosilane using Chiral Lewis bases as organocatalysts
Sugiura, Masaharu,Sato, Norimasa,Sonoda, Yuko,Kotani, Shunsuke,Nakajima, Makoto
supporting information; experimental part, p. 478 - 481 (2010/09/04)
Chiral Lewis base organocatalysts activate trichlorosilane to promote the tandem conjugate reduction/aldol reaction of α, β-unsaturated ketones with aldehydes to give optically active β-hydroxy ketones with good to high syn diastereo- and enantioselectivi
