124182-57-6

Basic information

• Product Name: CGS-21680 HYDROCHLORIDE
• Synonyms: 4-[2-[[6-Amino-9-(N-ethyl--D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic Acid Hydrochloride;2-p-(2-Carboxyethyl)phenethylamino-5μ-N-ethylcarboxamidoadenosine hydrate hydrochloride;CGS-21680 hydrate hydrochloride;4-[2-[[6-Amino-9-(N-ethyl-beta-D-ribofuranuronamidosyl)-9H-purin-yl]amino]ethyl]benzenepropanoic acid hydrochloride;2-p-(2-Carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride hydrate;CGS-21680 hydrochloride hydrate;3-{4-[2-({6-Amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl]-9H-purin-2-yl}amino)ethyl]phenyl}propanoic acid hydrochloride;2-(4-(2-((6-aMino-9-((3R,4S,5S)-5-(ethylcarbaMoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)aMino)ethyl)phenyl)acetic acid hydrochloride
• CAS NO: 124182-57-6
• Molecular Formula: C23H30ClN7O6
• Molecular Weight: 535.98
• Product Categories: Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Adenosine receptor
• Mol File: 124182-57-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 934.4°C at 760 mmHg
• Flash Point: 518.9°C
• Appearance: white/solid
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL
• CAS DataBase Reference: CGS-21680 HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CGS-21680 HYDROCHLORIDE(124182-57-6)
• EPA Substance Registry System: CGS-21680 HYDROCHLORIDE(124182-57-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 124182-57-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Biological Activity

A 2A adenosine receptor agonist (K i = 27 nM). Has affinity for A 1 and A 3 adenosine receptors but can be used to distinguish A 2A - and A 2B -mediated effects.

Biochem/physiol Actions

Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors.

InChI:InChI=1/C23H29N7O6.ClH/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H/t16?,17-,18-,22+;/m0./s1

Downstream Products

• 1352627-63-4 (R)-2-(3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanamido)-3-(1H-imidazol-4-yl)propanoic acid 
• 1352627-62-3 (S)-2-(3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanamido)-3-(1H-imidazol-4-yl)propanoic acid 
• 1352627-52-1 (R)-2-(3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanamido)succinic acid 
• 1352627-50-9 (S)-2-(3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanamido)succinic acid 
• 1352627-59-8 (R)-2-(3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanamido)-3-phenylpropanoic acid 
• 1352627-57-6 (S)-2-(3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanamido)-3-phenylpropanoic acid 
• 1352645-62-5 (R)-2-(3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanamido)-5-guanidinopentanoic acid