1241833-87-3Relevant academic research and scientific papers
Enantioselective Aza-morita-baylis-hillman reaction using aliphatic α-amidosulfones as imine surrogates
Abermil, Nacim,Masson, Geraldine,Zhu, Jieping
supporting information; experimental part, p. 656 - 660 (2010/06/19)
The bifunctional catalyst 6'-deoxy-6'-acylamino- β-isocupreidine (1) served both as a base to trigger the in situ generation of N-sulfonylimine from readily available α-amidosulfones and as a chiral nucleophile to initiate the enantioselective aza-Morita-Baylis-Hillman (aza-MBH) reaction. α-Methylene-β-amino-β-alkyl carbonyl compounds, difficultly accessible previously, can now be synthesized in excellent yields and enantioselectivities.
