1241850-53-2Relevant academic research and scientific papers
Highly diastereo-and enantioselective synthesis of monodifferentiated syn-1,2-diol derivatives through asymmetric transfer hydrogenation via dynamic kinetic resolution
Cartigny, Damien,Puentener, Kurt,Ayad, Tahar,Scalone, Michelangelo,Ratovelomanana-Vidal, Virginie
, p. 3788 - 3791 (2010)
The first enantio-and diastereoselective approach to α-alkoxy- substituted syn-β-hydroxyesters through highly efficient catalytic asymmetric transfer hydrogenation via dynamic kinetic resolution reactions from the corresponding racemic β-ketoesters is described. In this atom-economical process, two contiguous stereogenic centers are generated simultaneously with an excellent diastereoselectivity (up to 99/1) and enantioselectivity (up to 99%), allowing a rapid access to a wide variety of aromatic and heteroaromatic monodifferentiated syn-1,2-diols.
