1241859-82-4Relevant academic research and scientific papers
Direct palladium-catalyzed C-4 arylation of tri-substituted furans with aryl chlorides: An efficient access to heteroaromatics
Yang, Hai,Zheng, Zhishuo,Zeng, Jian,Liu, Huajie,Yi, Bing
, p. 2623 - 2626 (2012/10/29)
A series of functionalized furans were synthesized by way of a palladium -catalyzed coupling reaction of 2,3,5- trisubstituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of BuAd2P and t-BuOK in DMF at 120 °C after 15 h.
Palladium-catalyzed direct arylation reaction of 2,3,5-trisubstituted furans with aryl iodides or aryl bromides
Cao, Hua,Shen, Dongsheng,Zhan, Haiying,Yang, Liuqing
supporting information; experimental part, p. 1472 - 1476 (2011/08/03)
Pd-catalyzed direct arylation of 2,3,5-trisubstituted furans with a variety of aryl iodides or aryl bromides that showed high activity with reasonably broad scope was developed. Under optimal conditions, all reactions gave the desired products in moderate
Ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages
Cao, Hua,Zhan, Haiying,Shen, Dongsheng,Zhao, Hong,Liu, Yi
experimental part, p. 3086 - 3090 (2011/09/16)
A variety of functionalized furans were synthesized by way of a ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages. The feature of the reaction was facilitative preparation of furan derivative
Transition-metal-catalyzed domino reactions: Efficient one-pot regiospecific synthesis of highly functionalized polysubstituted furans from electron-deficient alkynes and 2-Yn-1-ols
Cao, Hua,Jiang, Huanfeng,Huang, Huawen
experimental part, p. 1019 - 1036 (2011/05/14)
Based on the reactive behavior of different transition-metal catalysts, three methods for the synthesis of highly functionalized polysubstituted furan derivatives are presented: (i) copper(I) iodide catalyzed regiospecific synthesis of furan aldehydes/ketones from alkynols and diethyl but-2-ynedioate under atmospheric pressure; (ii) nano-Cu-catalyzed domino process for the regioselective synthesis of -carbonylfurans from readily accessible starting materials; (iii) silver-catalyzed one-pot cyclization in toluene at 50 C for the synthesis of furan derivatives. It was notably that all the domino reactions were smooth under mild conditions with commercially available catalysts, and afforded highly functionalized furans in moderate to good yields. As we know, furans derivatives are extremely useful organic molecules used as synthetic building blocks for the synthesis of more elaborate heterocyclic compounds. Georg Thieme Verlag Stuttgart.
Silver-catalyzed one-pot cyclization reaction of electron-DEficient alkynes and 2-Yn-1-ols: An efficient domino process to polysubstituted furans
Cao, Hua,Jiang, Huanfeng,Mai, Ronghuan,Zhu, Shifa,Qi, Chaorong
supporting information; experimental part, p. 143 - 152 (2010/06/17)
Transition metal-catalyzed domino reactions have been used as powerful tools for the preparation of polysubstituted furans in a one-pot manner. In this paper, an efficient synthetic method was developed for the construction of tri- or tetrasubstituted furans from electron-deficient alkynes and 2-yn-1-ols by a silver-catalyzed domino reaction. It is especially noteworthy that a 2,3,5-trisubstituted 4-ynylfuran was formally obtained in an extremely direct manner without tedious stepwise synthesis. In addition, regio-isomeric furans were observed when substituted aryl alkynyl ketones were employed. This methodology represents a highly efficient synthetic route to electron-deficient furans for which catalytic approaches are scarce. The reaction proceeds efficiently under mild conditions with commercially available catalysts and materials.
