1241901-13-2

Upstream product

• 1241901-12-1 N-[3-O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-1-O-allyl-4,6-O-benzylidene-2-deoxy-α-D-glucopyranos-2-yl]-N'-(1-O-allyl-4,6-O-benzylidene-2,3-N,O-carbonyl-2-deoxy-α-D-glucopyranos-2-yl)urea 

Relevant academic research and scientific papers

A urea-linked glucosamine dimer as a building block for the synthesis of linear and cyclic neosaccharides

A novel urea-linked glucosamine dimer was obtained through a modification of the standard oxazolidinone closure reaction on a 2,3-amino alcohol monomer and fully characterized by NMR spectroscopy and by molecular mechanics and dynamics techniques. A mechanism was proposed for the dimerization reaction that was based on the formation of a 2,3-bis[(p-nitrophenoxy)carbonyl] intermediate, Chemoselective manipulations on the orthogonal protecting group pattern of the dimer - especially on its unprecedented oxazolidinone-urea-oxazolidinone system - gave an alcohol building block that was useful for access to higher linear and cyclic neosaccharides, The conformational features and 3Dcharacterization of a novel carbamate-linked neodisaccharide macrocycle was accomplished through molecular mechanics and dynamics calculations.