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1241905-03-2

methyl 3-(1-(dimethoxyphosphoryl)-2-methoxy-2-oxoethoxy)-2-hydroxybenzoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1241905-03-2 Structure

  • Basic information

    1. Product Name: methyl 3-(1-(dimethoxyphosphoryl)-2-methoxy-2-oxoethoxy)-2-hydroxybenzoate
    2. Synonyms: methyl 3-(1-(dimethoxyphosphoryl)-2-methoxy-2-oxoethoxy)-2-hydroxybenzoate
    3. CAS NO:1241905-03-2
    4. Molecular Formula:
    5. Molecular Weight: 348.246
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1241905-03-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl 3-(1-(dimethoxyphosphoryl)-2-methoxy-2-oxoethoxy)-2-hydroxybenzoate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl 3-(1-(dimethoxyphosphoryl)-2-methoxy-2-oxoethoxy)-2-hydroxybenzoate(1241905-03-2)
    11. EPA Substance Registry System: methyl 3-(1-(dimethoxyphosphoryl)-2-methoxy-2-oxoethoxy)-2-hydroxybenzoate(1241905-03-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1241905-03-2(Hazardous Substances Data)

1241905-03-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1241905-03-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,1,9,0 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1241905-03:
(9*1)+(8*2)+(7*4)+(6*1)+(5*9)+(4*0)+(3*5)+(2*0)+(1*3)=122
122 % 10 = 2
So 1241905-03-2 is a valid CAS Registry Number.

1241905-03-2Relevant articles and documents

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

Chiarelli, Laurent R.,Mori, Matteo,Barlocco, Daniela,Beretta, Giangiacomo,Gelain, Arianna,Pini, Elena,Porcino, Marianna,Mori, Giorgia,Stelitano, Giovanni,Costantino, Luca,Lapillo, Margherita,Bonanni, Davide,Poli, Giulio,Tuccinardi, Tiziano,Villa, Stefania,Meneghetti, Fiorella

, p. 754 - 763 (2018/06/26)

We report on the virtual screening, synthesis, and biological evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). A receptor-based virtual screening procedure was applied to screen the Enamine database, identifying two compounds, I and III, endowed with a good enzyme inhibitory activity. Considering the most active compound I as starting point for the development of novel MbtI inhibitors, we obtained new derivatives based on the furan scaffold. Among the SAR performed on this class, compound 1a emerged as the most potent MbtI inhibitor reported to date (Ki = 5.3 μM). Moreover, compound 1a showed a promising antimycobacterial activity (MIC99 = 156 μM), which is conceivably related to mycobactin biosynthesis inhibition.

Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site

Manos-Turvey, Alexandra,Cergol, Katie M.,Salam, Noeris K.,Bulloch, Esther M. M.,Chi, Gamma,Pang, Angel,Britton, Warwick J.,West, Nicholas P.,Baker, Edward N.,Lott, J. Shaun,Payne, Richard J.

, p. 9223 - 9236 (2013/01/15)

Mycobacterium tuberculosis salicylate synthase (MbtI) catalyses the first committed step in the biosynthesis of mycobactin T, an iron-chelating siderophore essential for the virulence and survival of M. tuberculosis. Co-crystal structures of MbtI with members of a first generation inhibitor library revealed large inhibitor-induced rearrangements within the active site of the enzyme. This plasticity of the MbtI active site was probed via the preparation of a library of inhibitors based on a 2,3-dihydroxybenzoate scaffold with a range of substituted phenylacrylate side chains appended to the C3 position. Most compounds exhibited moderate inhibitory activity against the enzyme, with inhibition constants in the micromolar range, while several dimethyl ester variants possessed promising anti-tubercular activity in vitro.

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

Manos-Turvey, Alexandra,Bulloch, Esther M. M.,Rutledge, Peter J.,Baker, Edward N.,Lott, J. Shaun,Payne, Richard J.

experimental part, p. 1067 - 1079 (2011/01/12)

Mycobacterium tuberculosis salicylate synthase (MbtI), a member of the chorismate-utilizing enzyme family, catalyses the first committed step in the biosynthesis of the siderophore mycobactin T. This complex secondary metabolite is essential for both viru

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