1241916-32-4Relevant academic research and scientific papers
One-pot straightforward approach to 2,3-disubstituted benzo/naphtho[b] furans via domino annulation of α-oxoketene dithioacetals and 1,4-benzo/naphthoquinone mediated by AlCl3 at room temperature
Verma, Girijesh Kumar,Verma, Rajiv Kumar,Shukla, Gaurav,Anugula, Nagaraju,Srivastava, Abhijeet,Singh, Maya Shankar
, p. 6612 - 6619 (2013/07/26)
A versatile and convenient one-pot direct approach to 2,3-disubstituted benzo/naphtho[b]furans via domino annulation of α-oxoketene dithioacetals and 1,4-benzo/naphthoquinone has been achieved in the presence of aluminium chloride at room temperature. Thi
Copper(II) bromide/boron trifluoride etherate-cocatalyzed cyclization of ketene dithioacetals and p-quinones: a mild and general approach to polyfunctionalized benzofurans
Liu, Yingjie,Wang, Mang,Yuan, Hongjuan,Liu, Qun
experimental part, p. 884 - 892 (2010/06/15)
A new application of copper(II) bromideactivated ketene dithioacetals as nucleophiles in organic chemistry has been developed. Under the cocatalysis of copper(II) bromide (2.0 mol%) and boron trifluoride etherate (10 mol%), the conjugate addition and sequential cyclization of a-electron-withdrawing group-substituted ketene dithioacetals with p-quinones in acetonitrile at room temperature gave a variety of benzofurans. This formal [3 + 2] cycloaddition provides a general method for catalytic synthesis of polyfunctionalized benzofurans with the ad-vantages of readily available starting materials, cheap catalysts, mild reaction conditions, good yields and wide range of synthetic potential for the benzofuran products. Further transformations of the resulting benzofurans to 2-aminobenzofurans and benzofuro[2,3-d]pyrimidine derivatives are also investigated.
