1241957-23-2Relevant academic research and scientific papers
METHOD FOR PRODUCING DIFLUOROCYCLOPROPANE COMPOUND
-
Page/Page column 10, (2012/11/08)
Provided is a method for producing a difluorocyclopropane compound under milder reaction conditions and with high selectivity and high yield. The method for producing a difluorocyclopropane compound of the present invention is characterized by using sodium bromodifluoroacetate as a difluorocyclopropanation agent. With the disclosed method, a difluorocyclopropane compound can be produced under milder reaction conditions and with a higher conversion rate and a higher yield compared to conventional art. Further, by-products can be reduced significantly, thus allowing waste to be greatly reduced. Accordingly, the production method of the present invention is easy to implement industrially (can be employed on an industrial scale) and is thus extremely practical and useful.
Sodium bromodifluoroacetate: A difluorocarbene source for the synthesis of gem -difluorocyclopropanes
Oshiro, Kojun,Morimoto, Yoshimichi,Amii, Hideki
scheme or table, p. 2080 - 2084 (2010/08/13)
As a new difluorocarbene source, sodium bromodifluoroacetate (BrCF 2CO2Na) was found to be effective for high-yielding synthesis of gem-difluorocyclopropanes and gem-difluorocyclopropenes under mild conditions. Georg Thieme Verlag Stuttgart.
