1241959-25-0Relevant articles and documents
Synthesis of eight 1-deoxynojirimycin isomers from a single chiral cyanohydrin
Van Den Nieuwendijk, Adrianus M.C.H.,Van Den Berg, Richard J.B H.N.,Ruben, Mark,Witte, Martin D.,Brussee, Johannes,Boot, Rolf G.,Van Der Marel, Gijsbert A.,Aerts, Johannes M.F.G.,Overkleeft, Herman S.
, p. 3437 - 3446 (2012)
Eight configurational 1-deoxynojirimycin isomers have been synthesized starting from a chiral cyanohydrin as the common precursor. The cyanohydrin chiral pool building block is easily accessible in large quantities by using almond hydroxynitrile lyase as the chiral catalyst in condensing hydrogen cyanide and crotonaldehyde. Our work complements the large body of literature on the synthesis of 1-deoxynojirimycin derivatives with the distinguishing feature that eight stereoisomers of this important class of glycosidase inhibitors can be derived from a common precursor in an efficient manner.