1242029-17-9Relevant academic research and scientific papers
Cyclobutene formation in PtCl2-catalyzed cycloisomerizations of heteroatom-tethered 1,6-enynes
Ni, Zhenjie,Giordano, Laurent,Tenaglia, Alphonse
, p. 11703 - 11706 (2014/10/15)
Aza(oxa)bicyclo[3.2.0]heptenes are accessed through the PtCl 2-catalyzed cycloisomerizations of heteroatom-tethered 1,6-enynes featuring a terminal alkyne and amide as the solvent. It is shown that the weak coordinating properties of the solven
Catalytic dicyanative 5-exo- And 6-endo-cyclization triggered by cyanopalladation of alkynes
Arai, Shigeru,Koike, Yuka,Nishida, Atsushi
supporting information; experimental part, p. 893 - 900 (2010/07/06)
A stereoselective dicyanative 5-exo- and 6endo-cyclization using various enynes has been investigated. The mode of cyclization is critically controlled by the structure of the substrates. For example, N-allyl derivatives prefer 5-exo-cyclization, while methacryloyl amides are transformed to the corresponding lactams with tetra substituted carbons at the alpha-position via 6-endo-cyclization. Both reactions include syn-cyanopalladation to carbon≡carbon triple bonds in the initial step, and sequential cyclization followed by reductive elimination in one operation enables the construction of the highly functionalized nitrogen heterocycles. The scope of suitable substrates and a proposed mechanism are also described.
