1242030-71-2Relevant academic research and scientific papers
Ortho, ortho′-Substituted KITPHOS monophosphines: Highly efficient ligands for palladium-catalyzed C-C and C-N bond formation
Doherty, Simon,Knight, Julian G.,McGrady, John P.,Ferguson, Alexandra M.,Ward, Nicholas A. B.,Harrington, Ross W.,Clegg, William
supporting information; experimental part, p. 201 - 211 (2010/06/20)
ortho, ortho′-Substitution of the phosphinoalkyne-derived aryl ring in KITPHOS (11-dicyclohexylphosphino-12-phenyl-9,10-ethenoanthracene) monophosphines enhances the performance of this class of ligand in palladium-catalyzed Suzuki-Miyaura cross-couplings and BuchwaldHartwig aminations, compared with their unsubstituted and mono-substituted counterparts. An alternative complementary synthesis of KITPHOS monophosphines has been developed and two new members of this family, 2,6-Me2-KITPHOS [11-dicyclohexylphosphino-12-(2,6-dimethylphenyl)-9,10-ethenoanthracene] and 2,6-(MeO)2-KITPHOS [11-dicyclohexylphosphino-12-(2,6-dimethoxyphenyl)-9,10-ethenoanthracene], have been prepared; palladium complexes of both are highly efficient catalysts for C - C and C - N bond formation with a range of electron-rich and electron-poor aromatic chlorides as well as heteroaryl chlorides.
