1242049-83-7Relevant academic research and scientific papers
On the role of DNA in DNA-based catalytic enantioselective conjugate addition reactions
Dijk, Ewold W.,Boersma, Arnold J.,Feringa, Ben L.,Roelfes, Gerard
, p. 3868 - 3873 (2010)
A kinetic study of DNA-based catalytic enantioselective Friedel-Crafts alkylation and Michael addition reactions showed that DNA affects the rate of these reactions significantly. Whereas in the presence of DNA, a large acceleration was found for the Friedel-Crafts alkylation and a modest acceleration in the Michael addition of dimethyl malonate, a deceleration was observed when using nitromethane as nucleophile. Also, the enantioselectivities proved to be dependent on the DNA sequence. In comparison with the previously reported Diels-Alder reaction, the results presented here suggest that DNA plays a similar role in both cycloaddition and conjugate addition reactions.
