1242061-34-2Relevant academic research and scientific papers
The plakotenins: Biomimetic diels-alder reactions, total synthesis, structural investigations, and chemical biology
Bourcet, Emmanuel,Kaufmann, Larissa,Arzt, Stephanie,Bihlmeier, Angela,Klopper, Wim,Schepers, Ute,Br?se, Stefan
, p. 15004 - 15020 (2013/01/15)
The total synthesis of plakotenin, a cytotoxic marine natural product, using a biomimetic Diels-Alder reaction is described in detail. Two approaches were used, whereby the Diels-Alder reaction occurs at different stages of the synthesis. Homo-and nor-pla
Enantioselective total synthesis of plakotenin, a cytotoxic metabolite from Plakortis sp
Arzt, Stephanie,Bourcet, Emmanuel,Muller, Thierry,Braese, Stefan
experimental part, p. 3300 - 3306 (2010/08/21)
The first total enantioselective synthesis of plakotenin is described. This marine natural product was isolated from an Okinawan sponge of the genus Plakortis and shows potent biological activity against several cancerous cell lines. A biomimetic intramolecular Diels-Alder reaction served as a key step in the total synthesis. The synthesis proves the relative and absolute stereochemistry of natural plakotenin. The Royal Society of Chemistry 2010.
