1242078-22-3

Upstream product

• 110-91-8 morpholine 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

TiO2–SiO2 Catalyzed Eco-friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3-d]pyrimidine Derivatives

A cost-effective and eco-friendly synthesis of benzopyrano[2,3-d]pyrimidine derivatives has been developed via three component one-pot tandem approach by condensing different salicylaldehydes and secondary amines with malononitrile in the presence of TiO2–SiO2 catalyst at 80°C under solvent-free conditions. Mild experimental conditions, reusability of the catalyst, and cost effectiveness are the merits of this procedure. Compounds 4g, 4h, and 4i bearing 2-OMe group on the hydroxyphenyl group linked to the central carbon present in between the two nitrogen atoms of the pyrimidine ring were found to exhibit good antioxidant activity while other compounds have moderate antioxidant activity.

Synthesis of benzopyrano[2,3-d]pyrimidines using silica-bonded N-propylpiperazine sodium N-propionate as heterogeneous solid base catalyst under solvent-free conditions

Silica-bonded N-propylpiperazine sodium Npropionate is employed as a recyclable heterogeneous solid base catalyst for the synthesis of benzopyrano[2,3-d]pyrimidines through one-pot condensation reaction of salicylaldehydes, malononitrile, and secondary amines at room temperature under solvent-free conditions. The catalyst could be recycled several times without appreciable loss in catalytic activity.

Sodium formate-catalyzed one-pot synthesis of benzopyranopyrimidines and 4-thio-substituted 4H-chromenes via multicomponent reaction at room temperature

A simple, straightforward and highly efficient multicomponent one-pot synthesis of a series of pharmaceutically interesting benzopyranopyrimidine and 4H-chromene derivatives has been developed on the basis of low-cost and environment-friendly sodium forma

Covalently anchored 2-amino ethyl-3-propyl imidazolium bromideon SBA-15 as a green, efficient and reusable Br?nsted basic ionic liquid nanocatalyst for one-pot solvent-free synthesis of benzopyranopyrimidines under ultrasonic irradiation

In the present study, highly ordered mesoporous SBA-15 having Br?nsted basic ionic liquid pore channels was synthesized via a surfactant-templated sol-gel methodology and a post modification process. For this, well ordered mesoporous chloro-functionalized

Silica nanoparticles immobilized benzoylthiourea ferrous complex as an efficient and reusable catalyst for one-pot synthesis of benzopyranopyrimidines

Benzoylthiourea Fe(II) complex was supported on silica nanoparticles and employed as a heterogeneous catalyst in preparation of benzopyranopyrimidines through one-pot condensation reaction of salicylaldehydes, malononitrile and secondary amines in EtOH, a

ZrOCl2?8H2O as an efficient catalyst for the pseudo four-component synthesis of benzopyranopyrimidines

An efficient and environmentally benign protocol for the pseudo four-component synthesis of benzopyranopyrimidines via condensation of salicylic aldehydes, malononitrile and various amines catalyzed by ZrOCl2?8H2O as an inexpensive and eco-friendly catalyst with high catalytic activity under solvent-free conditions is reported. This protocol provides a new and improved method for obtaining benzopyranopyrimidines in terms of good yields, simple experimental procedure and short reaction time.

Pseudo four-component synthesis of benzopyranopyrimidines

An efficient and simple method for the synthesis of new benzopyranopyrimidines via a pseudo four-component reaction of salicylic aldehydes, malononitrile and various amines in the presence of a catalytic amount of LiClO4 is reported. The advantages of this procedure are mild reaction conditions, high yields of products and operational simplicity.