1242142-76-2Relevant academic research and scientific papers
Benzoxazine and benzodioxine as indole isosteres in indolocarbazoles series: Synthesis and biological evaluation
Ayerbe, Nathalie,Routier, Sylvain,Gillaizeau, Isabelle,Tardy, Sebastien,Coudert, Gerard
experimental part, p. 121 - 126 (2010/09/15)
New series of structure based on original benzodioxine and benzoxazine heterocycles were prepared leading to potential anticancer lead compounds. In this paper, we described a convenient approach via a Diels-Alder cycloaddition in order to efficiently provide three new indole isosteres in indolocarbazoles series. Their first cytotoxic evaluation was also reported.
