1242157-14-7

Basic information

• Product Name: 5-BroMo-7-fluoro-1-indanone
• Synonyms: 5-BroMo-7-fluoro-1-indanone;5-broMo-7-fluoro-2,3-dihydro-1H-inden-1-one;5-bromo-7-fluoro-2,3-dihydroinden-1-one
• CAS NO: 1242157-14-7
• Molecular Formula: C9H6BrFO
• Molecular Weight: 229.0457432
• Mol File: 1242157-14-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-BroMo-7-fluoro-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-7-fluoro-1-indanone(1242157-14-7)
• EPA Substance Registry System: 5-BroMo-7-fluoro-1-indanone(1242157-14-7)

Safety Data

• Hazardous Substances Data: 1242157-14-7(Hazardous Substances Data)

Usage

Uses

5-Bromo-7-fluoro-1-indanone is a reagent used in the synthesis of RN486, a pharmaceutical used in the treatment of Rhematoid Arthritis, via BTK inhibition.

Upstream product

• 151982-51-3 4-bromo-2-fluorobenzoyl chloride 
• 112704-79-7 2-fluoro-4-bromobenzoic acid 
• 395639-63-1 1-(4-bromo-2-fluorophenyl)-3-chloro-propan-1-one 

Downstream Products

• 1242157-15-8 6-bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one 
• 1242156-23-5 6-cyclopropyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(4-methyl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-2H-isoquinolin-1-one 
• 1242156-55-3 2-(3-chloro-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinoline-1(2H)-one 
• 1242156-54-2 2-chloro-6-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2 (1H)-yl)benzaldehyde 
• 1242156-53-1 6-cyclopropyl-8-fluoro-1-oxoisoquinoline-2-(1H)-one 
• 1242157-65-8 6-cyclopropyl-2-(3-{5-[5-(4-ethylpiperazin-1-yl)pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydropyridin-3-yl}-2-hydroxymethylphenyl)-8-fluoro-2H-isoquinolin-1-one 

Relevant articles and documents

HETEROARYL PYRIDONE AND AZA-PYRIDONE AMIDE COMPOUNDS

Heteroaryl pyridone and aza-pyridone amide compounds of Formula (I) are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-Phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-III: wherein, variables Q, R, X, X′, Y1, Y2, Y2′, Y3, Y4, Y5, m, and n are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.