1242175-34-3 Usage
Uses
(2R,3R,1’S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
Check Digit Verification of cas no
The CAS Registry Mumber 1242175-34-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,2,1,7 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1242175-34:
(9*1)+(8*2)+(7*4)+(6*2)+(5*1)+(4*7)+(3*5)+(2*3)+(1*4)=123
123 % 10 = 3
So 1242175-34-3 is a valid CAS Registry Number.
1242175-34-3Relevant articles and documents
Synthesis of all enantiomerically pure diastereomers of aprepitant
Gangula, Srinivas,Elati, Chandrashekhar R.,Mudunuru, Satish Varma,Nardela, Anitha,Dongamanti, Ashok,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 2254 - 2268 (2010/09/11)
Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and X-ray crystallographic analysis were achieved. Copyrigh
