1242183-69-2Relevant academic research and scientific papers
Synthesis and anti-inflammatory activity of some 3-(4,6-disubtituted-2- thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives
Mokale, Santosh N.,Shinde, Sandeep S.,Elgire, Rupali D.,Sangshetti, Jaiprakash N.,Shinde, Devanand B.
experimental part, p. 4424 - 4426 (2010/09/09)
A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed significant (p 0.05) anti-inflammatory activity.
