1242274-80-1Relevant academic research and scientific papers
Synthesis and biological evaluation of cytotoxic activity of novel anthracene l-rhamnopyranosides
Song, Gaopeng,Liu, Hongchun,Zhang, Wei,Geng, Meiyu,Li, Yingxia
, p. 5183 - 5193 (2010)
A series of anthracene l-rhamnopyranosides were designed and synthesized in a practical way and their cytotoxic activity was examined in vitro. Most compounds exhibited both potent cytotoxicity against several tumor cell lines and high DNA binding capacity. The preliminary results showed that subtle modifications of rhamnosyl moiety in anthracene rhamnosides with acetyl group had a selective toxicity for different tumor cells and the displacement of C-10 carbonyl group in emodin by acetylmethylene group was helpful to improve the inhibitory activity. Lipophilicity of the anthracene glycosides was not a crucial factor for cytotoxicity and most molecules with good cytotoxicity could inhibit the catalytic activity of Top2α.
Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives
Ding, Ning,Zhang, Zaihong,Zhang, Wei,Chun, Yuexing,Wang, Peng,Qi, Huimin,Wang, Shan,Li, Yingxia
experimental part, p. 2126 - 2135 (2011/11/06)
A series of novel oligorhamnoside derivatives (1-10) and naturally occurring cleistrioside-5 were synthesized and evaluated for their in vitro antibacterial activities. Among them, dirhamnoside derivative 7 and cleistrioside-5 displayed similar antibacter
