1242276-85-2Relevant academic research and scientific papers
FLUCONAZOLE CARBOXYLIC ESTER DERIVATIVES, SYNTHESIS, AND USE IN LONG ACTING FORMULATIONS
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Page/Page column 20-21, (2010/09/18)
This invention relates to compounds represented by the structural Formula (1), and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein: m is from 8 to 16, R' is a C1-4 alkyl group, and R1 is selected from the group consisting of C1-6 alkyl, C3-8 alkenyl, C3-12 cycloalkyl, phenyl, phenylethenyl and hydrogen, wherein each of said alkyl, cycloalkyl or phenyl may be substituted with one or more electron-withdrawing groups, hydrogen, and salts thereof wherein a negative charge is associated to a monovalent cation. These compounds are useful pharmaceutical agents with improved solubility and bioavailability characteristics.
