1242309-63-2Relevant academic research and scientific papers
Double diastereoselective, nucleophile-catalyzed aldol lactonizations (NCAL) leading to β-lactone fused carbocycles and extensions to β-lactone fused tetrahydrofurans
Morris, Kay A.,Arendt, Kevin M.,Oh, Seong Ho,Romo, Daniel
supporting information; experimental part, p. 3764 - 3767 (2010/11/04)
A double diastereoselective variant of the nucleophile-catalyzed aldol lactonization (NCAL) process is described. This strategy delivers β-lactone-fused carbocycles with good to excellent diastereoselectivities using cinchona alkaloid catalysts with enantioenriched aldehyde acids, which gave low diastereoselectivity based on substrate control alone. β-Lactone-fused tetrahydrofurans are also prepared for the first time via the NCAL process; however, diastereoselectivity was only modestly improved when applying double diastereodifferentiation to these systems.
