1242329-10-7Relevant academic research and scientific papers
Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization
Shinozuka, Tsuyoshi,Tsukada, Tomoharu,Fujii, Kunihiko,Tokumaru, Eri,Shimada, Kousei,Onishi, Yoshiyuki,Matsui, Yumi,Wakimoto, Satoko,Kuroha, Masanori,Ogata, Tsuneaki,Araki, Kazushi,Ohsumi, Jun,Sawamura, Ryoko,Watanabe, Nobuaki,Yamamoto, Hideki,Fujimoto, Kazunori,Tani, Yoshiro,Mori, Makoto,Tanaka, Jun
, p. 5099 - 5117 (2018/09/17)
Attempts were made to reduce the lipophilicity of previously synthesized compound (II) for the avoidance of hepatotoxicity. The replacement of the left-hand side benzene with 2-pyridine resulted in the substantial loss of potency. Because poor membrane pe
