1242337-75-2Relevant academic research and scientific papers
Stereoselective bromination of 2-vinyl chromones using NBS
Bhatnagar, Seema,Kaushik, Swati,Sahi, Shakti
, p. 219 - 226 (2011)
A simple one-step synthetic methodology for stereoselective synthesis of E- and Z-3-bromo-2-vinyl chromones in quantitative yield in polar solvents under ambient conditions without the use of catalysts is reported. Copyright Taylor & Francis Group, LLC.
Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line
Bhatnagar, Seema,Sahi, Shakti,Kackar, Puneet,Kaushik, Swati,Dave, Manan K.,Shukla, Akshara,Goel, Ashita
scheme or table, p. 4945 - 4950 (2010/10/02)
The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERβ binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.
