1242341-45-2Relevant academic research and scientific papers
Asymmetric addition of indoles to isatins catalysed by bifunctional modified cinchona alkaloid catalysts
Chauhan, Pankaj,Chimni, Swapandeep Singh
, p. 7709 - 7713 (2010)
(Figure Presented) Simple and selective: An efficient organocatalytic enantioselective method for the synthesis of substituted-3-hydroxyoxindole derivatives with a quaternary chiral carbon has been developed. The cinchona alkaloid derived catalyst catalyses the Friedel Crafts-type addition of indole derivatives to the isatin derivatives under mild conditions to provide substituted 3-hydroxyoxindoles in good to excellent yields with high enantioselectivity (see scheme).
