124238-56-8

Basic information

• Product Name: Alkyne-PEGn-Alkyne 2K, 5K, 10K, 20K
• Synonyms: Alkyne-PEGn-Alkyne 2K, 5K, 10K, 20K
• CAS NO: 124238-56-8
• Molecular Weight: 0
• Product Categories: Polydispersed PEG
• Mol File: 124238-56-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in Water, DMSO, DCM, DMF
• CAS DataBase Reference: Alkyne-PEGn-Alkyne 2K, 5K, 10K, 20K(CAS DataBase Reference)
• NIST Chemistry Reference: Alkyne-PEGn-Alkyne 2K, 5K, 10K, 20K(124238-56-8)
• EPA Substance Registry System: Alkyne-PEGn-Alkyne 2K, 5K, 10K, 20K(124238-56-8)

Safety Data

• Hazardous Substances Data: 124238-56-8(Hazardous Substances Data)

Usage

Description

1,2-Bis(2-propynyloxy)ethane, also known as Bis-propargyl-PEG12, is a homobifunctional crosslinker that can participate in Click Chemistry to yield a stable triazole linkage with azide. Copper is needed as a catalyst for this reaction. The presence of a PEG chain in the molecule greatly improves its hydrophilicity.

Uses

Used in Pharmaceutical Industry:
1,2-Bis(2-propynyloxy)ethane is used as a crosslinker for the development of drug delivery systems. Its hydrophilic nature allows for improved solubility and bioavailability of drugs, enhancing their therapeutic efficacy.
Used in Bioconjugation:
1,2-Bis(2-propynyloxy)ethane is used as a crosslinker in bioconjugation processes, enabling the stable attachment of biological molecules such as proteins, peptides, and nucleic acids to various surfaces or other biomolecules.
Used in Materials Science:
1,2-Bis(2-propynyloxy)ethane is used as a crosslinker in the synthesis of hydrogels, polymers, and other materials with improved mechanical properties and stimuli-responsive behavior.
Used in Chemical Synthesis:
1,2-Bis(2-propynyloxy)ethane is used as an intermediate in the synthesis of various organic compounds, taking advantage of its reactivity in Click Chemistry reactions to form stable triazole linkages.