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1242419-39-1

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1242419-39-1 Usage

General Description

R-3,3'-Bis(4-methylphenyl)-1,1'-bi-2-naphthol, also known as BINOL, is a chiral molecule with two naphthol groups linked by a central biaryl axis. It is widely used as a chiral ligand in asymmetric catalysis, particularly in metal-catalyzed asymmetric transformations. BINOL and its derivatives have been utilized in a variety of reactions, such as the asymmetric addition of diethylzinc to aldehydes and the asymmetric allylation of aldehydes. Its unique structure and high enantioselectivity make it a valuable tool in organic synthesis and the production of pharmaceuticals and fine chemicals. BINOL is also known for its ability to effectively discriminate between different enantiomers, making it an important compound in the field of chiral resolution and separation techniques.

Check Digit Verification of cas no

The CAS Registry Mumber 1242419-39-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,2,4,1 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1242419-39:
(9*1)+(8*2)+(7*4)+(6*2)+(5*4)+(4*1)+(3*9)+(2*3)+(1*9)=131
131 % 10 = 1
So 1242419-39-1 is a valid CAS Registry Number.

1242419-39-1Downstream Products

1242419-39-1Relevant articles and documents

Novel Axially Chiral Ligand-Enabled Copper-Catalyzed Asymmetric Oxidative Coupling of 2-Naphthols for the Synthesis of 6,6′-Disubstituted BINOLs

Wang, Pengyang,Cen, Shouyi,Gao, Jun,Shen, Ahui,Zhang, Zhipeng

, p. 2321 - 2326 (2022/04/07)

Novel axially chiral ligands have been designed and synthesized by merging the chelating picolinic acid with substituted BINOLs. The in-situ-prepared copper catalysts from the ligands and CuI enable the asymmetric oxidative coupling of 2-naphthols, afford

Efficient synthesis of 3,3'-diaryl binaphthol through a one-step method

-

Paragraph 0042-0044, (2018/07/30)

The invention relates to a class of catalysis reactions of binaphthol and halogenated aromatic hydrocarbons, particularly to efficient preparation of 3,3'-diaryl binaphthol and 3-Bulkyaryl binaphtholthrough a one-step method, and belongs to the technical field of asymmetric catalysis. A purpose of the present invention is to provide a simple and practical method for preparing 3,3'-diaryl binaphthol through a one-step reaction of inexpensive BINOL and a brominated aromatic hydrocarbon reagent, and is further to provide a simple and rapid method for conveniently preparing 3-aryl binaphthol withhigh steric hindrance.

Expedient BINOL derivative arylations

Albini, Mathieu,Taillier, Catherine,Dalla, Vincent,Blanchet, Jér?me,Rouden, Jacques

, p. 6420 - 6422 (2014/12/10)

A dramatic improvement of our previous methodology based on a Suzuki-Miyaura cross-coupling to access 3,3′-disubstituted H8-BINOLs using microwave heating is reported herein. These new conditions represent a large gain in term of atom-economy, reaction time, catalyst loading, and excess of reagents employed.

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